Research and Publications

Please find a publication list of the Discipline below

2012:

Intersubtype differences in the effect of a rare p24 Gag mutation on HIV-1 replicative fitness.  Denis R Chopera, Laura A Cotton, Alexander Zawaira, Jaclyn K Mann, Nobubelo K Ngandu, Roman Ntale, Jonathan M Carlson, Koleka Mlisana, Zenda Woodman, Debra de Assis Rosa, Toshiyuki Miura, Florencia Pereyra, Bruce D Walker, Clive M Gray, Darren P Martin, Thumbi Ndung'u, Mark A Brockman, Salim Abdool Karim, Zabrina L Brumme, Carolyn Williamson.  Journal of virology. 09/2012;

 

Beneficial HLA-mediated viral polymorphisms on the transmitted virus additively influence disease progression in HIV-1, subtype C infection Retrovirology 2012, 9(Suppl 2):O60

RS Ntale, DR Chopera, NK Ngandu, M Abrahams, A Debra, M Mlotswa, L Werner, Z Woodman, K Mlisana, S Karim, CM Gray, C Williamson, CAPRISA 002 AI Study Team AIDS Vaccine, Boston; 09/2012

Increased Memory Differentiation Is Associated with Decreased Polyfunctionality for HIV but Not for Cytomegalovirus-Specific CD8+ T Cells.

Catherine Riou, Florette Treurnicht, Melissa-Rose Abrahams, Koleka Mlisana, Michael K P Liu, Nilu Goonetilleke, Richard Koup, Mario Roederer, Salim Abdool Karim, Guy de Bruyn, Carolyn Williamson, Clive M Gray, Wendy A Burgers

Journal of immunology (Baltimore, Md. : 1950). 09/2012;

 

Temporal association of HLA-B*81:01 and B*39:10 mediated HIV-1 p24 sequence evolution with disease progression. Journal of Virology – 2012

R.S. Ntale, D.R. Chopera, N.K. Ngandu, D. Assis de Rosa, M. Mlotshwa, L. Werner, Z. Woodman, K. Mlisana, S. Abdool Karim, C.M. Gray, C. Williamson, the CAPRISA 002 Study Team.

Safety of tenofovir gel, a vaginal microbicide, in South African women: results of the CAPRISA 004 Trial.  David C Sokal, Quarraisha Abdool Karim, Sengeziwe Sibeko, Nonhlanhla Yende-Zuma, Leila E Mansoor, Cheryl Baxter, Anneke Grobler, Janet Frolich, Ayesha Bm Kharsany, Zaheen Omar, Nomsa Miya, Koleka Mlisana, Silvia Maarshalk, Salim S Abdool Karim

Antiviral therapy. 08/2012;

P15-13. HVTN 503(Phambili) trial discontinuation of enrolment/vaccination: the impact on trial participant attitudes to vaccine trials and scientific researchD Mark, K Middelkoop, S Roux, G Gray, K Mlisana, M Nchabaleng, G Churchyard, G De Bruyn, M Latka, D Magagula, J Kublin, M Allen, L Bekker, TNIAID HIV Vaccine Trials Network
04/2012; 6:1-1.

Symptomatic vaginal discharge is a poor predictor of sexually transmitted infections and genital tract inflammation in high-risk women in South Africa.

Koleka Mlisana, Nivashnee Naicker, Lise Werner, Lindi Roberts, Francois van Loggerenberg, Cheryl Baxter, Jo-Ann S Passmore, Anneke C Grobler, A Willem Sturm, Carolyn Williamson, Katharina Ronacher, Gerhard Walzl, Salim S Abdool KarimThe Journal of infectious diseases. 04/2012; 206(1):6-14.

HIV Prevention in High-Risk Women in South Africa: Condom Use and the Need for Change for the CAPRISA 002 Acute Infection Study Team

Francois Van Loggerenberg, Alexis A Dieter, Magdalena E Sobieszczyk, Lise Werner, Anneke Grobler, Koleka Mlisana.  PLoS ONE. 02/2012;

 

2011

Genital tract inflammation during early HIV-1 infection predicts higher plasma viral load set point in women.  Lindi Roberts, Jo-Ann S Passmore, Koleka Mlisana, Carolyn Williamson, Francesca Little, Lisa M Bebell, Gerhard Walzl, Melissa-Rose Abrahams, Zenda Woodman, Quarraisha Abdool Karim, Salim S Abdool KarimThe Journal of infectious diseases. 01/2012; 205(2):194-203.

 

Virological and immunological factors associated with HIV-1 differential disease progression in HLA-B 58:01-positive individuals.  D R Chopera, M Mlotshwa, Z Woodman, K Mlisana, D de Assis Rosa, D P Martin, S Abdool Karim, C M Gray, C WilliamsonJournal of virology. 07/2011; 85(14):7070-80.

 

Safety and efficacy of the HVTN 503/Phambili study of a clade-B-based HIV-1 vaccine in South Africa: a double-blind, randomised, placebo-controlled test-of-concept phase 2b study.  Glenda E Gray, Mary Allen, Zoe Moodie, Gavin Churchyard, Linda-Gail Bekker, Maphoshane Nchabeleng, Koleka Mlisana, Barbara Metch, Guy de Bruyn, Mary H Latka, [......], Matsontso Mathebula, Nivashnee Naicker, Constance Ducar, Donald K Carter, Adrien Puren, Niles Eaton, M Julie McElrath, Michael Robertson, Lawrence Corey, James G KublinThe Lancet infectious diseases. 07/2011; 11(7):507-15. ·

 

Novel polycyclic 'cage'-1,2-diamines as potential anti-tuberculosis agents.

Oluseye K Onajole; Yacoob Coovadia; Hendrik G Kruger; Glenn E M Maguire; Melendhran Pillay; Thavendran Govender.  Eur J Med Chem 54, 1 (2012) 

 

Mycobacterium tuberculosis isolates grown under oxygen deprivation invade pulmonary epithelial cells.  Olubisi T Ashiru; Manormoney Pillay; A Willem Sturm.

Anaerobe 18, 471 (2012)

 

Emergence and treatment of multidrug resistant (MDR) and extensively drug-resistant (XDR) tuberculosis in South Africa.

Elizabeth M Streicher; Borna Müller; Violet Chihota; Charmaine Mlambo; Marisa Tait; Manormoney Pillay; Andre Trollip; Kim G P Hoek; Frederick A Sirgel; Nicolaas C Gey van Pittius; et al.  Infect. Genet. Evol. 12, 686 (2012)

 

Population structure of multi- and extensively drug-resistant Mycobacterium tuberculosis strains in South Africa.

Violet N Chihota; Borna Müller; Charmaine K Mlambo; Manormoney Pillay; Marisa Tait; Elizabeth M Streicher; Else Marais; Gian D van der Spuy; Madeleine Hanekom; Gerrit Coetzee; et al.  J. Clin. Microbiol. 50, 995 (2012)

 

Total synthesis of a depsidomycin analogue by convergent solid-phase peptide synthesis and macrolactonization strategy for antitubercular activity.

Venugopala K Narayanaswamy; Fernando Albericio; Yacoob Mohamed Coovadia; Hendrik G Kruger; Glenn E M Maguire; Melendhran Pillay; Thavendran Govender.

J. Pept. Sci. 17, 683 (2011)

 

An outbreak of foodborne salmonellosis in rural KwaZulu-Natal, South Africa.

Niehaus AJ, Apalata T, Coovadia YM, Smith AM, Moodley P.  Foodborne Pathog Dis. 2011 Jun;8(6):693-7. Epub 2011 Mar 9.

 

 

2010:

Adhesion to and invasion of pulmonary epithelial cells by the F15/LAM4/KZN and Beijing strains of Mycobacterium tuberculosis.

Olubisi T Ashiru; Manormoney Pillay; A Willem Sturm.  J. Med. Microbiol. 59, 528 (2010)

 

Nosocomial transmission of the F15/LAM4/KZN genotype of Mycobacterium tuberculosis in patients on tuberculosis treatment.

M Pillay; A W Sturm.  Int. J. Tuberc. Lung Dis. 14, 223 (2010)

 

Short communication decreased incidence of dual infections in South african subtype C-infected women compared to a cohort ten years earlier.

Zenda Woodman; Koleka Mlisana; Florette Treurnicht; Melissa-Rose Abrahams; Ruwayida Thebus; Salim Abdool Karim; Carolyn Williamson;

AIDS Res. Hum. Retroviruses 27, 1167 (2011)


 

Association of polymorphisms in the LEDGF/p75 gene (PSIP1) with susceptibility to HIV-1 infection and disease progression.  Paradise Madlala; Rik Gijsbers; Frauke Christ; Anneleen Hombrouck; Lise Werner; Koleka Mlisana; Ping An; Salim S Abdool Karim; Cheryl A Winkler; Zeger Debyser; et al.

AIDS 25, 1711 (2011)


 

Virological and immunological factors associated with HIV-1 differential disease progression in HLA-B 58:01-positive individuals.

D R Chopera; M Mlotshwa; Z Woodman; K Mlisana; D de Assis Rosa; D P Martin; S Abdool Karim; C M Gray; C Williamson;  J. Virol. 85, 70700 (2011)


 

Safety and efficacy of the HVTN 503/Phambili study of a clade-B-based HIV-1 vaccine in South Africa: a double-blind, randomised, placebo-controlled test-of-concept phase 2b study.  Glenda E Gray; Mary Allen; Zoe Moodie; Gavin Churchyard; Linda-Gail Bekker; Maphoshane Nchabeleng; Koleka Mlisana; Barbara Metch; Guy de Bruyn; Mary H Latka; et al.  Lancet Infect Dis 11, 507 (2011)


 

Duffy-null-associated low neutrophil counts influence HIV-1 susceptibility in high-risk South African black women.  Veron Ramsuran; Hemant Kulkarni; Weijing He; Koleka Mlisana; Edwina J Wright; Lise Werner; John Castiblanco; Rahul Dhanda; Tuan Le; Matthew J Dolan; et al.  Clin. Infect. Dis. 52, 1248 (2011)


 

The neutralization breadth of HIV-1 develops incrementally over four years and is associated with CD4+ T cell decline and high viral load during acute infection.

Elin S Gray; Maphuti C Madiga; Tandile Hermanus; Penny L Moore; Constantinos Kurt Wibmer; Nancy L Tumba; Lise Werner; Koleka Mlisana; Sengeziwe Sibeko; Carolyn Williamson; et al.  J. Virol. 85, 48280 (2011)


 

Co-enrollment in multiple HIV prevention trials - experiences from the CAPRISA 004 Tenofovir gel trial.  Quarraisha Abdool Karim; Ayesha B M Kharsany; Kasavan Naidoo; Nonhlanhla Yende; Tanuja Gengiah; Zaheen Omar; Natasha Arulappan; Koleka P Mlisana; Londiwe R Luthuli; Salim S Abdool Karim (2011)

 

Potent and broad neutralization of HIV-1 subtype C by plasma antibodies targeting a quaternary epitope including residues in the V2 loop.

Penny L Moore; Elin S Gray; Daniel Sheward; Maphuti Madiga; Nthabeleng Ranchobe; Zhong Lai; William J Honnen; Molati Nonyane; Nancy Tumba; Tandile Hermanus; et al.  J. Virol. 85, 3128 (2011)


 

Recruitment of high risk women for HIV prevention trials: baseline HIV prevalence and sexual behavior in the CAPRISA 004 tenofovir gel trial.

Quarraisha Abdool Karim; Ayesha Bm Kharsany; Janet A Frohlich; Cheryl Baxter; Nonhlanhla Yende; Leila E Mansoor; Koleka P Mlisana; Silvia Maarschalk; Natasha Arulappan; Anneke Grobler; et al.

Trials 12, 670 (2011)
Centre for the AIDS Programme of Research in South Africa (CAPRISA), Nelson R Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa.

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Association of TRIM22 with the type 1 interferon response and viral control during primary HIV-1 infection.

Ravesh Singh; Gaurav Gaiha; Lise Werner; Kevin McKim; Koleka Mlisana; Jeremy Luban; Bruce D Walker; Salim S Abdool Karim; Abraham L Brass; Thumbi Ndung'u; et al.  J. Virol. 85, 2080 (2011)


 

Fluidity of HIV-1-specific T-cell responses during acute and early subtype C HIV-1 infection and associations with early disease progression.  Mandla Mlotshwa; Catherine Riou; Denis Chopera; Debra de Assis Rosa; Roman Ntale; Florette Treunicht; Zenda Woodman; Lise Werner; Francois van Loggerenberg; Koleka Mlisana; et al.  J. Virol. 84, 120180 (2010)


 

Effectiveness and safety of tenofovir gel, an antiretroviral microbicide, for the prevention of HIV infection in women.  Quarraisha Abdool Karim; Salim S Abdool Karim; Janet A Frohlich; Anneke C Grobler; Cheryl Baxter; Leila E Mansoor; Ayesha B M Kharsany; Sengeziwe Sibeko; Koleka P Mlisana; Zaheen Omar; et al.  Science 329, 11680 (2010)


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Mannose-rich glycosylation patterns on HIV-1 subtype C gp120 and sensitivity to the lectins, Griffithsin, Cyanovirin-N and Scytovirin.

Kabamba B Alexandre; Elin S Gray; Bronwen E Lambson; Penny L Moore; Isaac A Choge; Koleka Mlisana; Salim S Abdool Karim; James McMahon; Barry O'Keefe; Rachel Chikwamba; et al.  Virology 402, 187 (2010)


 

Plasma cytokine levels during acute HIV-1 infection predict HIV disease progression.  Lindi Roberts; Jo-Ann S Passmore; Carolyn Williamson; Francesca Little; Lisa M Bebell; Koleka Mlisana; Wendy A Burgers; Francois van Loggerenberg; Gerhard Walzl; Joel F Djoba Siawaya; et al.  AIDS 24, 8190 (2010)


 

Adaptive changes in HIV-1 subtype C proteins during early infection are driven by changes in HLA-associated immune pressure.  F K Treurnicht; C Seoighe; D P Martin; N Wood; M-R Abrahams; D de Assis Rosa; H Bredell; Z Woodman; W Hide; K Mlisana; et al.  Virology 396, 2130 (2010)


 

APOBEC3G expression is dysregulated in primary HIV-1 infection and polymorphic variants influence CD4+ T-cell counts and plasma viral load.  Kavidha Reddy; Cheryl A Winkler; Lise Werner; Koleka Mlisana; Salim S Abdool Karim; Thumbi Ndung'u;  AIDS 24, 195 (2010)


 

HIV-Selectest enzyme immunoassay and rapid test: ability to detect seroconversion following HIV-1 infection.  Surender Khurana; Philip J Norris; Michael P Busch; Barton F Haynes; Susan Park; Pretty Sasono; Koleka Mlisana; Abdool Karim Salim; Frederick M Hecht; Joseph Mulenga; et al.

J. Clin. Microbiol. 48, 281 (2010)


 

A rare case  of HSV and PCP co-infection in a patient with AIDS  : A diagnostic and  management Challenge. Mitha, Reddy, Parboosing, Coovadia Y M.  SAMJ 2010

 

 

Group B Streptococcus and Acinetobacter baumanii meningitis in a neonate.  V Howell , P  Mahabeer, Y M Coovadia, 2010

 

 

Prevalence of antimicrobial resistant bacteria from adult ICUs and the Burns unit at a large tertiary hospital in Durban. Khine Swe Swe/ Han, Y Coovadia. Int J Infect Control 2010, v6:i2 doi: 10.3396/ijic.V6i2.015.10

 

 

The  aetiology of acute community acquired bacterial meningitis in children and adults in Maputo, Mozambique.  Tomás F. Zimba, David T. Nota , José C. Langa, Leonel G. S. Monteiro and Yacoob M.  Coovadia.

 

Acinetobacter baumannii and group B streptococcus co-infection causing neonatal meningitis.  Victoria Howell, Prasha Mahabeera, Yacoob Coovadia and Radhika Singh.  IOS Press. 2010

 

Cryptococcus meningitis and skin lesions in an HIV negative child.. K Swe Swe/ Han, A Bekker, S Greeff, D R Perkins. J Clin Pathol 2008; 000 1-3. doi: 10.1136/ jcp.2008.056119.

  

Molecular typing and antifungal susceptibility of clinical and environmental C. neoformans species complex isolates in the city of Goiania, Brazil. Silva Mariado Rosario et al;  Mycoses journal, MYC-OA-2008-132).

 

Intra-venous glucose preparation as the source of an outbreak of extended spectrum -lactamase producing Klebsiella pneumoniae infections in the neonatal unit  of a regional hospital in KwaZulu-Natal.     Moodley P, Coovadia Y, Sturm AW.   SAMJ   2006


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